Science
The safety and efficacy of therapeutic drugs still requires improvement. However, the advent of both systems biology and precision medicine has stimulated a rethink on the process of therapeutic drug design and polypharmacology. More recently, the definition of polypharmacology has morphed to represent therapeutic drugs that have been designed deliberately for multi-targeting that affords beneficial effects to the patient. This emerging effort has been labelled ‘Systems Pharmacology’ and the products are referred to as multi-target or systems pharmacology drugs. This episode is part 1 of 2 episodes on the topic of systems pharmacology, and covers human complexity, systems biology and precision medicine. Original article by Dr Kirkwood A. Pritchard Jr, Dr Dustin P. Martin and Dr Stephen Naylor If you'd like to view the original article then follow the link below: https://www.ddw-online.com/therapeutics/p322783-perspective-on-systems-pharmacology:-when-multi-targeting-is-advantageous.html You can also download the original article pdf here: https://www.ddw-online.com/media/32/135186/(4)-perspective-on-systems.pdf For more information on Drug Discovery World, head to: https://www.ddw-online.com