Guest: Caroline Hastings, MD Guest: Raymond Y. Wang, MD Niemann-Pick disease type C (NPC) is an ultra-rare, inherited, neurodegenerative disease with life-threatening complications. Due to its highly variable onset of neurological symptoms throughout one’s lifespan, recognizing and establishing diagnosis for NPC can be challenging for any clinician. That’s why Drs. Caroline Hastings and Raymond Y. Wang join Dr. Jennifer Caudle to help address those challenges with a detailed look at this genetic condition, the factors underlying its variable onset and course, and strategies to improve recognition, cross-specialty communications, and time to diagnosis. Copyright ©2021 Orphazyme A/S. All rights reserved.NP-USA-1492-v1ORPHAZYME is a trademark or registered trademark of Orphazyme A/S.

Focus on Neurology and Psychiatry

Closing Gaps in the Recognition & Detection of Niemann-Pick Disease Type C

Guest: Timothy William West, MD Here to discuss staying ahead of progression in patients with relapsing multiple sclerosis (RMS) is Dr. Timothy William West. Dr. West walks us through pathophysiological changes in progressing RMS patients, a patient case demonstrating why patients may experience increasing disability, and key data on MAYZENT®(siponimod), the first and only oral disease-modifying therapy studied and proven to delay disability progression in a more progressed RMS patient population, including active SPMS. MAYZENT was evaluated in EXPAND—the largest Phase III study of secondary progressive MS (SPMS) patients to date (N=1651), which included a broad range of patients with moderate-to-advanced disability. Dr. West discusses clinical data from EXPAND including data of up to 5 years from a preplanned interim analysis of the EXPAND open-label extension study.

Staying Ahead of Progression in RMS

Host: Jennifer Caudle, DO Guest: Kathleen Blake, MD, MPH Guest: Peggy Chen, MD Behavioral health integration has proven to be an effective solution to improving access to treatment for many mental health conditions… So why is it not more prevalent in the medical community? Joining Dr. Jennifer Caudle to dive into the findings and implications of the joint AMA-RAND Corporation study recently published in the Annals of Internal Medicine are Dr. Kathleen Blake with the AMA and Dr. Peggy Chen from the RAND Corporation. And, click here to listen to a conversation regarding Behavioral Health Integration and its effect on clinical practice.

Investigating the Adoption of Behavioral Health Integration

Guest: Andrew Cutler, MD In Chapter 1 of this three-part series that’s designed to help increase the awareness and understanding of the pathophysicology and comorbidities in patients with bipolar disorder or schizophrenia, Dr. Cutler explores the pathophysicology and some comorbidities in patients with bipolar disorder. This is an informational non-CME program sponsored by Alkermes, Inc. ALKERMES® is a registered trademark of Alkermes, Inc. KEEP THE BODY IN MIND® is a registered service mark of Alkermes Pharma Ireland Limited, used by Alkermes, Inc., under license. ©2020 Alkermes, Inc. All rights reserved. None of the subjects pictured are actual patients. UNB-002745

Bipolar Disorder: Pathophysiology and Comorbidities

Guest: Andrew Cutler, MD Take a closer look at the pathophysiology of schizophrenia and a range of physical comorbidities with Dr. Cutler in Chapter 2 of this three-part series for the “Keep the Body in Mind” initiative. This is an informational non-CME program sponsored by Alkermes, Inc. ALKERMES® is a registered trademark of Alkermes, Inc. KEEP THE BODY IN MIND® is a registered service mark of Alkermes Pharma Ireland Limited, used by Alkermes, Inc., under license. ©2020 Alkermes, Inc. All rights reserved. None of the subjects pictured are actual patients. UNB-002974 

Schizophrenia: Pathophysiology and Comorbidities

Guest: Andrew Cutler, MD In the third and final chapter of this series for the “Keep the Body in Mind” initiative, Dr. Cutler discusses strategies that could improve care for patients with bipolar disorder or schizophrenia and talks about recommendations for evaluating and monitoring health conditions. This is an informational non-CME program sponsored by Alkermes, Inc. ALKERMES® is a registered trademark of Alkermes, Inc. KEEP THE BODY IN MIND® is a registered service mark of Alkermes Pharma Ireland Limited, used by Alkermes, Inc., under license. ©2020 Alkermes, Inc. All rights reserved. None of the subjects pictured are actual patients. UNB-002975

Opportunities to Manage the Whole Patient with Bipolar Disorder or Schizophrenia

Host: Mario R. Nacinovich, Jr., MSc Guest: Paul Orchard, MD Although it only affects about one in 18,000 people, the impacts of adrenoleukodystrophy cannot be underestimated. That’s why Dr. Paul Orchard joins Mario Nacinovich to talk about this rare—and fatal—genetic disease, why it’s often underdiagnosed and confused with other conditions, and how we can treat it once we’ve reached an accurate diagnosis.

Keys to Avoiding an Adrenoleukodystrophy Misdiagnosis

Host: Mimi Secor, DNP, FNP-BC, FAANP Guest: James B, Potash, MD, MPH Psychopharmacology is the study of genetic variations to pinpoint more effective personalized treatments for psychiatric disorders. But with clinicians, industry heads, insurance providers, and regulating agencies all weighing in on this practice and forming varying opinions, what’s the best way to move forward? Here to answer that question and others with Dr. Mimi Secor is Dr. James Potash, a Professor of Psychiatry and Behavioral Sciences and Psychiatrist in Chief at the John Hopkins Department of Psychiatry. 

Genetic Testing for Psychiatric Disorders: Is It Ready for Primetime?

Host: Brian P. McDonough, MD, FAAFP Guest: Kisma Orbovich Improvement is something we’re all constantly chasing, whether it’s in the form of a promotion, a bigger house, or maybe even an ideal weight. So why do we often fail miserably at these attempts to make our lives better? To get to the bottom of this dilemma, Dr. Brian McDonough is joined by Kisma Orbovich, the CEO of Illumination Academy, to reveal the secret to true success and how gratitude may just be the lifehack we’ve been searching for.

Strategies for Success: Exercising Our Mental Muscle

Host: Brian P. McDonough, MD, FAAFP Guest: Teresa Gil, PhD Since about 21 million mothers in America experienced sexual abuse in their childhood, there’s a good chance that some of these women are our patients. So as their physicians, how can we provide them with the best possible care as they continue to cope with the lifelong effects of sexual abuse? That’s what Dr. Brian McDonough explores with Dr. Teresa Gil, author of Women Who Were Sexually Abused as Children: Mothering, Resilience, and Protecting the Next Generation.

The Lasting Effects of Childhood Sexual Abuse: Fighting the Lifelong Battle

Host: Patricia K. Coyle, MD Guest: Clyde E. Markowitz, MD Please note: This activity is no longer available for continuing education credit. Multiple sclerosis (MS) is one of the leading causes of disability worldwide. As the treatment armamentarium continues to grow, patient involvement in the development of an effective treatment strategy is becoming increasingly important. In this Clinical ExchangesSM activity, leading MS specialists discuss issues of diagnosing MS, initiating treatment, and switching therapies, all in the context of practical shared decision-making techniques demonstrated by their own patients. 

Detangling Difficult Conversations About Multiple Sclerosis: Clinical Exchanges

New research and clinical trials yield frequent developments in neuroscience and mental health. ReachMD welcomes an array of leading thinkers who lend their focused expertise to these principles, central to human function and ability.